SOLiD PIfASE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF OXYTOCIN CARBA ANALOGUES CONTATh'ING THREONINE IN POSITION 4*
نویسنده
چکیده
Solid phase methodology was developed for the synthesis of carba-analogues of oxytocin. Two known compounds (deaminc-l-carba-oxytocin (I) and deamino-fi-carba-oxytocin (II) and two new analogues ((4-threonine]deamino-l-carba-oxytocin (III) and [4-threoninc}deamino-6-carba-oxytocin (IV» were synthesized using different approaches. The latter two compounds were found to possess high biological activity in the rat uterotonic (ill vitro and ill vivo) and galactogogic (ill vivo) assays.
منابع مشابه
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